Immunology of the mouse mammary tumor virus (MTV) : identification in vitro of mouse antibodies against MTV.
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منابع مشابه
Immunology of the mouse mammary tumor virus (MTV): neutralization of MTV by mouse antiserum.
years; antisera from rabbits, rats, and guinea pigs immunized with MTV-containing tissue extracts are capable of neutralizing the biologic activity of the virus (1, 2, 3, 6, 9). More recently, it has been demonstrated that MTV is also immunogenic in the mouse; antisera from immunized mice react with MTV antigen in immunodiffusion to produce a precipitate line specific for MTV (5, 11). The prese...
متن کاملHuman antibodies binding to the mouse mammary tumor virus: a nonspecific reaction?
Specific rabbit antisera and over 100 human sera were found to precipitate iodinated mouse mammary tumor virus (MTV). The specificity of these reactions was tested in competitive inhibition studies. Three classes of reaction could be distinguished. The Class 1 reaction was the most specific; it could be inhibited only by MTV and was observed exclusively with rabbit anti-MTV. The Class 2 reactio...
متن کاملIdentification of the Mtv-2 gene responsible for the early appearance of mammary tumors in the GR mouse by nucleic acid hybridization.
In the mouse strain GR, the Mtv-2 gene controls the expression of large amounts of mammary tumor virus (MTV) antigens in the milk at first lactation. It also controls the early appearance of mammary tumors. We have investigated the number of MTV proviral sequences associated with this Mtv-2 gene by nucleic acid hybridization between MTV [(3)H]cDNA and DNA from GR, B10, and GR-Mtv-2(-) mice. B10...
متن کاملStudies on mouse mammary tumor virus (MTV) and mouse leukemia virus (MuLV) by immunoelectron microscopy.
Antigenic properties of the mouse mammary tumor virus (MTV or type B) particles and of the murine leukemia virus (MuLV or type C) particles have been studied by immunoelectron microscopy. Mouse mammary tumor cell lines producing either both type B and type C virus particles or only B or C type particles have been used. Mouse reticulum cell sarcoma and rat bone tumor cell lines producing type C ...
متن کاملLocalization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain
The GR/Mtv-2- mouse strain is congenic to the GR strain but lacks the Mtv-2 gene for high amounts of mouse mammary tumor virus (MMTV) virion particles in the milk and early mammary tumors. With a sensitive competition radioimmunoassay for individual viral proteins of MMTV, substantial amounts of the gag proteins p27 and p10 could still be detected in extracts of the mammary glands of GR/Mtv-2- ...
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ورودعنوان ژورنال:
- Cancer research
دوره 26 4 شماره
صفحات -
تاریخ انتشار 1966